TY - JOUR

T1 - Age of First Arrhythmic Event in Brugada Syndrome

T2 - Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

AU - Milman, Anat

AU - Andorin, Antoine

AU - Gourraud, Jean-Baptiste

AU - Sacher, Frederic

AU - Mabo, Philippe

AU - Kim, Sung-Hwan

AU - Maeda, Shingo

AU - Takahashi, Yoshihide

AU - Kamakura, Tsukasa

AU - Aiba, Takeshi

AU - Conte, Giulio

AU - Juang, Jimmy J M

AU - Leshem, Eran

AU - Rahkovich, Michael

AU - Hochstadt, Aviram

AU - Mizusawa, Yuka

AU - Postema, Pieter G

AU - Arbelo, Elena

AU - Huang, Zhengrong

AU - Denjoy, Isabelle

AU - Giustetto, Carla

AU - Wijeyeratne, Yanushi D

AU - Napolitano, Carlo

AU - Michowitz, Yoav

AU - Brugada, Ramon

AU - Casado-Arroyo, Ruben

AU - Champagne, Jean

AU - Calo, Leonardo

AU - Sarquella-Brugada, Georgia

AU - Tfelt-Hansen, Jacob

AU - Priori, Silvia G

AU - Takagi, Masahiko

AU - Veltmann, Christian

AU - Delise, Pietro

AU - Corrado, Domenico

AU - Behr, Elijah R

AU - Gaita, Fiorenzo

AU - Yan, Gan-Xin

AU - Brugada, Josep

AU - Leenhardt, Antoine

AU - Wilde, Arthur A M

AU - Brugada, Pedro

AU - Kusano, Kengo F

AU - Hirao, Kenzo

AU - Nam, Gi-Byoung

AU - Probst, Vincent

AU - Belhassen, Bernard

N1 - © 2017 American Heart Association, Inc.

PY - 2017/12

Y1 - 2017/12

N2 - BACKGROUND: Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE.METHODS AND RESULTS: A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3% men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2%) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years).CONCLUSIONS: SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.

AB - BACKGROUND: Data on the age at first arrhythmic event (AE) in Brugada syndrome are from limited patient cohorts. The aim of this study is 2-fold: (1) to define the age at first AE in a large cohort of patients with Brugada syndrome, and (2) to assess the influence of the mode of AE documentation, sex, and ethnicity on the age at first AE.METHODS AND RESULTS: A survey of 23 centers from 10 Western and 4 Asian countries gathered data from 678 patients with Brugada syndrome (91.3% men) with first AE documented at time of aborted cardiac arrest (group A, n=426) or after prophylactic implantable cardioverter-defibrillator implantation (group B, n=252). The vast majority (94.2%) of the patients were 16 to 70 years old at the time of AE, whereas pediatric (<16 years) and elderly patients (>70 years) comprised 4.3% and 1.5%, respectively. Peak AE rate occurred between 38 and 48 years (mean, 41.9±14.8; range, 0.27-84 years). Group A patients were younger than in Group B by a mean of 6.7 years (46.1±13.2 versus 39.4±15.0 years; P<0.001). In adult patients (≥16 years), women experienced AE 6.5 years later than men (P=0.003). Whites and Asians exhibited their AE at the same median age (43 years).CONCLUSIONS: SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) presents the first analysis on the age distribution of AE in Brugada syndrome, suggesting 2 age cutoffs (16 and 70 years) that might be important for decision-making. It also allows gaining insights on the influence of mode of arrhythmia documentation, patient sex, and ethnic origin on the age at AE.

KW - Adolescent

KW - Adult

KW - Age of Onset

KW - Aged

KW - Brugada Syndrome/physiopathology

KW - Defibrillators, Implantable

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Prognosis

U2 - 10.1161/CIRCEP.117.005222

DO - 10.1161/CIRCEP.117.005222

M3 - Journal article

C2 - 29254945

VL - 10

JO - Circulation: Arrhythmia and Electrophysiology

JF - Circulation: Arrhythmia and Electrophysiology

SN - 1941-3149

IS - 12

M1 - e005222

ER -