Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan

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Standard

Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan. / Shan, Muhammad Adnan; Mechlenborg, Julie; Røgen, Rebecca; Børsting, Claus; Morling, Niels.

In: Forensic Sciences Research, Vol. 7, No. 2, 2022, p. 202-206.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Shan, MA, Mechlenborg, J, Røgen, R, Børsting, C & Morling, N 2022, 'Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan', Forensic Sciences Research, vol. 7, no. 2, pp. 202-206. https://doi.org/10.1080/20961790.2021.1933366

APA

Shan, M. A., Mechlenborg, J., Røgen, R., Børsting, C., & Morling, N. (2022). Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan. Forensic Sciences Research, 7(2), 202-206. https://doi.org/10.1080/20961790.2021.1933366

Vancouver

Shan MA, Mechlenborg J, Røgen R, Børsting C, Morling N. Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan. Forensic Sciences Research. 2022;7(2):202-206. https://doi.org/10.1080/20961790.2021.1933366

Author

Shan, Muhammad Adnan ; Mechlenborg, Julie ; Røgen, Rebecca ; Børsting, Claus ; Morling, Niels. / Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan. In: Forensic Sciences Research. 2022 ; Vol. 7, No. 2. pp. 202-206.

Bibtex

@article{8a391d87a29d48fd98428b22bdbcbb4a,
title = "Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan",
abstract = "We investigated the forensic efficacy of the 30 insertion/deletion (Indel) markers included in the Qiagen Investigator{\textregistered} DIPplex kit in 529 Pakistani individuals from five major subpopulations in Pakistan (Punjabi, Pashtun, Sindhi, Saraiki, and Baloch). In the Sindhi population, the distribution of HLD81 and HLD97 alleles deviated from Hardy-Weinberg equilibrium after Bonferroni correction. The combined match probability ranged from 2.0E-12 (Pashtun and Baloch) to 1.0E-12 (Sindhi), and the mean paternity exclusion power varied from 0.995 (Punjabi, Sindhi, and Saraiki) to 0.996 (Pashtun and Baloch). The high combined power of discrimination (0.999 999 999 999 97) and low combined match probability (1.7E-12) for all subpopulations studied support the utility of the 30 Indel markers for forensic identification in the studied subpopulations. The allele frequencies of the Indel markers in the Pakistani subpopulations were compared with those from 18 other populations. The results show that the populations clustered according to geography. The subpopulations investigated in this work showed a close genetic relationship with others from Pakistan, as well as with South Central Asian and Middle Eastern populations. The results suggest that the Investigator{\textregistered} DIPplex kit can be useful as a supplementary tool for human identification in the five Pakistani subpopulations investigated in this study. Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1933366.",
keywords = "anthropology, forensic genetics, Forensic sciences, individual identification, investigator DIPplex kit, population genetics, Qiagen",
author = "Shan, {Muhammad Adnan} and Julie Mechlenborg and Rebecca R{\o}gen and Claus B{\o}rsting and Niels Morling",
note = "Publisher Copyright: {\textcopyright} 2021 The Author(s). Published by Taylor & Francis Group on behalf of the Academy of Forensic Science.",
year = "2022",
doi = "10.1080/20961790.2021.1933366",
language = "English",
volume = "7",
pages = "202--206",
journal = "Forensic Sciences Research",
issn = "2096-1790",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Anthropological analyses of 30 insertion/deletion autosomal markers in five major ethnic groups of Pakistan

AU - Shan, Muhammad Adnan

AU - Mechlenborg, Julie

AU - Røgen, Rebecca

AU - Børsting, Claus

AU - Morling, Niels

N1 - Publisher Copyright: © 2021 The Author(s). Published by Taylor & Francis Group on behalf of the Academy of Forensic Science.

PY - 2022

Y1 - 2022

N2 - We investigated the forensic efficacy of the 30 insertion/deletion (Indel) markers included in the Qiagen Investigator® DIPplex kit in 529 Pakistani individuals from five major subpopulations in Pakistan (Punjabi, Pashtun, Sindhi, Saraiki, and Baloch). In the Sindhi population, the distribution of HLD81 and HLD97 alleles deviated from Hardy-Weinberg equilibrium after Bonferroni correction. The combined match probability ranged from 2.0E-12 (Pashtun and Baloch) to 1.0E-12 (Sindhi), and the mean paternity exclusion power varied from 0.995 (Punjabi, Sindhi, and Saraiki) to 0.996 (Pashtun and Baloch). The high combined power of discrimination (0.999 999 999 999 97) and low combined match probability (1.7E-12) for all subpopulations studied support the utility of the 30 Indel markers for forensic identification in the studied subpopulations. The allele frequencies of the Indel markers in the Pakistani subpopulations were compared with those from 18 other populations. The results show that the populations clustered according to geography. The subpopulations investigated in this work showed a close genetic relationship with others from Pakistan, as well as with South Central Asian and Middle Eastern populations. The results suggest that the Investigator® DIPplex kit can be useful as a supplementary tool for human identification in the five Pakistani subpopulations investigated in this study. Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1933366.

AB - We investigated the forensic efficacy of the 30 insertion/deletion (Indel) markers included in the Qiagen Investigator® DIPplex kit in 529 Pakistani individuals from five major subpopulations in Pakistan (Punjabi, Pashtun, Sindhi, Saraiki, and Baloch). In the Sindhi population, the distribution of HLD81 and HLD97 alleles deviated from Hardy-Weinberg equilibrium after Bonferroni correction. The combined match probability ranged from 2.0E-12 (Pashtun and Baloch) to 1.0E-12 (Sindhi), and the mean paternity exclusion power varied from 0.995 (Punjabi, Sindhi, and Saraiki) to 0.996 (Pashtun and Baloch). The high combined power of discrimination (0.999 999 999 999 97) and low combined match probability (1.7E-12) for all subpopulations studied support the utility of the 30 Indel markers for forensic identification in the studied subpopulations. The allele frequencies of the Indel markers in the Pakistani subpopulations were compared with those from 18 other populations. The results show that the populations clustered according to geography. The subpopulations investigated in this work showed a close genetic relationship with others from Pakistan, as well as with South Central Asian and Middle Eastern populations. The results suggest that the Investigator® DIPplex kit can be useful as a supplementary tool for human identification in the five Pakistani subpopulations investigated in this study. Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1933366.

KW - anthropology

KW - forensic genetics

KW - Forensic sciences

KW - individual identification

KW - investigator DIPplex kit

KW - population genetics

KW - Qiagen

U2 - 10.1080/20961790.2021.1933366

DO - 10.1080/20961790.2021.1933366

M3 - Journal article

C2 - 35784406

AN - SCOPUS:85113589063

VL - 7

SP - 202

EP - 206

JO - Forensic Sciences Research

JF - Forensic Sciences Research

SN - 2096-1790

IS - 2

ER -

ID: 279756340