Lung hypoplasia - A possible teratogenic effect of valproate
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Lung hypoplasia - A possible teratogenic effect of valproate. / Janas, Mette Stagaard; Arrøe, Mette; Hansen, Steen Holger; Græm, Niels.
In: APMIS, Vol. 106, No. 2, 1998, p. 300-304.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Lung hypoplasia - A possible teratogenic effect of valproate
AU - Janas, Mette Stagaard
AU - Arrøe, Mette
AU - Hansen, Steen Holger
AU - Græm, Niels
PY - 1998
Y1 - 1998
N2 - Three cases of lung hypoplasia occurring in two siblings and in an unrelated child are reported. All three cases had been exposed to valproate in utero. The two female siblings had no other malformations, whereas the third female had a number of defects consistent with the fetal valproate syndrome. Thus, none of the known major causes of lung hypoplasia was present in any of the three cases. It is discussed whether pulmonary hypoplasia may be a separate disease entity, or caused by prenatal exposure to valproate.
AB - Three cases of lung hypoplasia occurring in two siblings and in an unrelated child are reported. All three cases had been exposed to valproate in utero. The two female siblings had no other malformations, whereas the third female had a number of defects consistent with the fetal valproate syndrome. Thus, none of the known major causes of lung hypoplasia was present in any of the three cases. It is discussed whether pulmonary hypoplasia may be a separate disease entity, or caused by prenatal exposure to valproate.
KW - Lung hypoplasia
KW - Pulmonary hypoplasia
KW - Teratogenic effect
KW - Valproate
UR - http://www.scopus.com/inward/record.url?scp=0031888341&partnerID=8YFLogxK
U2 - 10.1111/j.1699-0463.1998.tb01350.x
DO - 10.1111/j.1699-0463.1998.tb01350.x
M3 - Journal article
C2 - 9531963
AN - SCOPUS:0031888341
VL - 106
SP - 300
EP - 304
JO - Acta Pathologica et Microbiologica Scandinavica - Section A Pathology
JF - Acta Pathologica et Microbiologica Scandinavica - Section A Pathology
SN - 0365-4184
IS - 2
ER -
ID: 338985994