Two cases of lysergamide intoxication by ingestion of seeds from Hawaiian Baby Woodrose
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Two cases of lysergamide intoxication by ingestion of seeds from Hawaiian Baby Woodrose. / Klinke, Helene Bendstrup; Müller, Irene Breum; Steffenrud, Steffen; Dahl-Sørensen, Rasmus.
I: Forensic Science International, Bind 197, Nr. 1-3, 15.04.2010, s. e1-e5.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Two cases of lysergamide intoxication by ingestion of seeds from Hawaiian Baby Woodrose
AU - Klinke, Helene Bendstrup
AU - Müller, Irene Breum
AU - Steffenrud, Steffen
AU - Dahl-Sørensen, Rasmus
N1 - Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
PY - 2010/4/15
Y1 - 2010/4/15
N2 - We describe two cases of human consumption of seeds from Argyreia nervosa (Hawaiian Baby Woodrose), which resulted in one fatality due to falling from a building and one surviving witness. The principal psychoactive constituent of the seeds, lysergamide (LSA), was recovered from blood and urine samples by mixed-mode cation exchange solid-phase extraction and quantified by ultra performance liquid chromatography-time of flight mass spectrometry (UPLC-ToF/MS). The LSA concentrations were determined by UPLC-ToF/MS to be 4.9 microg/L in blood and 1.0mg/L in urine in the dead person and 1.8 microg/L in blood and 0.50mg/L in urine in the living person. These analytical findings were found to be in accordance with the case story, which indicated that seeds had been ingested and also noted psychological reactions, i.e. the will to jump out of the window. Other findings in the dead person were 22 microg/L THC in blood, 0.71 g/L ethanol in blood and 1.0 g/L ethanol in vitreous humor. Constituents originating from the seeds of A. nervosa, i.e. LSA, ergonovine, lysergic acid alpha-hydroxyethylamide were also identified in the biological samples. The 2-hydroxy-3-oxo metabolites of LSA and ergonovine were identified in the urine sample of the deceased.
AB - We describe two cases of human consumption of seeds from Argyreia nervosa (Hawaiian Baby Woodrose), which resulted in one fatality due to falling from a building and one surviving witness. The principal psychoactive constituent of the seeds, lysergamide (LSA), was recovered from blood and urine samples by mixed-mode cation exchange solid-phase extraction and quantified by ultra performance liquid chromatography-time of flight mass spectrometry (UPLC-ToF/MS). The LSA concentrations were determined by UPLC-ToF/MS to be 4.9 microg/L in blood and 1.0mg/L in urine in the dead person and 1.8 microg/L in blood and 0.50mg/L in urine in the living person. These analytical findings were found to be in accordance with the case story, which indicated that seeds had been ingested and also noted psychological reactions, i.e. the will to jump out of the window. Other findings in the dead person were 22 microg/L THC in blood, 0.71 g/L ethanol in blood and 1.0 g/L ethanol in vitreous humor. Constituents originating from the seeds of A. nervosa, i.e. LSA, ergonovine, lysergic acid alpha-hydroxyethylamide were also identified in the biological samples. The 2-hydroxy-3-oxo metabolites of LSA and ergonovine were identified in the urine sample of the deceased.
U2 - 10.1016/j.forsciint.2009.11.017
DO - 10.1016/j.forsciint.2009.11.017
M3 - Journal article
C2 - 20018470
VL - 197
SP - e1-e5
JO - Forensic Science International
JF - Forensic Science International
SN - 0379-0738
IS - 1-3
ER -
ID: 20120379