A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein
Research output: Contribution to journal › Journal article › Research › peer-review
This overview on the brain-serum relationship for drugs illustrates the importance of the drug transporter P-glycoprotein at the blood-brain barrier. Generally, an inverse relationship exists between the magnitude of the brain-serum ratio and the influence of P-glycoprotein. Concerning the pharmacogenomics of P-glycoprotein, no clear effect of single nucleotide polymorphisms (SNPs) has been demonstrated in humans.
Original language | English |
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Journal | Drug Metabolism and Drug Interactions |
Volume | 22 |
Issue number | 2-3 |
Pages (from-to) | 113-29 |
Number of pages | 16 |
ISSN | 0792-5077 |
Publication status | Published - 2007 |
Bibliographical note
Keywords: Animals; Blood-Brain Barrier; Brain; Humans; Mice; P-Glycoprotein; Pharmaceutical Preparations; Pharmacokinetics; Rats; Structure-Activity Relationship
ID: 13918172