An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.
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We present an oxcarbazepine-related fatality together with an overview of 26 postmortem cases involving oxcarbazepine observed during the period 2001-2006. The fatality case concerned a 27-year-old woman with epilepsy, who was found dead in her bed. Oxcarbazepine and its active metabolite, 10-hydroxycarbazepine, were the only compounds detected. The concentrations of oxcarbazepine were as follows: femoral blood, 2.9 mg/kg; muscle, 1.8 mg/kg; liver, 0.9 mg/kg; gastric content (300 ml), 860 mg/kg; and vitreous humour, not detected. The concentrations of 10-hydroxycarbazepine were as follows: femoral blood, 66 mg/kg; muscle, 40 mg/kg; liver, 62 mg/kg; gastric content, 27 mg/kg; and vitreous humour, 25 mg/kg. The analyses were performed by HPLC-DAD after liquid-liquid extraction. Oxcarbazepine intoxication was regarded as a possible cause of death. For the other 26 cases, the 10-hydroxycarbazepine concentrations ranged from 2.2 to 48 mg/kg with a median of 25 mg/kg.
Original language | English |
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Journal | Forensic Science International |
Volume | 177 |
Issue number | 2-3 |
Pages (from-to) | 248-251 |
Number of pages | 4 |
ISSN | 0379-0738 |
DOIs | |
Publication status | Published - 2008 |
ID: 10091819