Bundle branch block in cardiac arrest survivors without ischemic heart disease
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Bundle branch block in cardiac arrest survivors without ischemic heart disease. / Holm, Julie Terp; Stampe, Niels Kjær; Bhardwaj, Priya; Jabbari, Reza; Gustafsson, Finn; Risum, Niels; Tfelt-Hansen, Jacob; Winkel, Bo Gregers.
In: IJC Heart and Vasculature, Vol. 45, 101188, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Bundle branch block in cardiac arrest survivors without ischemic heart disease
AU - Holm, Julie Terp
AU - Stampe, Niels Kjær
AU - Bhardwaj, Priya
AU - Jabbari, Reza
AU - Gustafsson, Finn
AU - Risum, Niels
AU - Tfelt-Hansen, Jacob
AU - Winkel, Bo Gregers
N1 - Funding Information: The project was supported by the Novo Nordisk foundation (Tandem Programme; #31634), the John og Birth Meyer foundation, the Danish Heart Foundation (17-R116-A7484-22079) and University Hospital Copenhagen, Rigshospitalets Science board.
PY - 2023
Y1 - 2023
N2 - Aims: Cardiac arrest (CA) survivors with left/right bundle branch block (LBBB/RBBB) and no ischemic heart disease (IHD) have not been previously characterized. The aim of this study was to describe heart failure, implantable cardioverter defibrillator (ICD) therapy and mortality in this population. Methods: Between 2009 and 2019 we consecutively identified all CA survivors with a consistent bundle branch block (BBB) defined as a QRS ≥ 120 ms, who had a secondary prophylactic ICD implanted. Patients with congenital and ischemic heart disease (IHD) were excluded. Results: Among 701 CA-survivors who survived to discharge and received an ICD, a total of 58 (8%) were free from IHD and had BBB; 46 (79%) had LBBB, 10 (17%) had RBBB and 2 (3%) had non-specific BBB (NSBBB). The prevalence of LBBB was 7%. Pre-arrest ECG were available in 34 (59%) patients; 20 patients (59%) had LBBB, 6 (18%) had RBBB, 2 (6%) had NSBBB, 1 had (3%) incomplete LBBB, and 4 (12%) without BBB. At discharge, patients with LBBB had a significantly lower left ventricular ejection fraction (LVEF) than patients with other types of BBB, p < 0.001. During follow-up, 7 (12%) died after a median of 3.6 years (IQR: 2.6–5.1) with no difference between BBB subtypes. Conclusion: We identified 58 CA-survivors with BBB and no IHD. The prevalence of LBBB among all CA-survivors was high, 7%. During CA hospitalization LBBB patients presented with a significantly lower LVEF than patients with other types of BBB (P < 0.001). ICD treatment and mortality did not differ between BBB subtypes during follow-up.
AB - Aims: Cardiac arrest (CA) survivors with left/right bundle branch block (LBBB/RBBB) and no ischemic heart disease (IHD) have not been previously characterized. The aim of this study was to describe heart failure, implantable cardioverter defibrillator (ICD) therapy and mortality in this population. Methods: Between 2009 and 2019 we consecutively identified all CA survivors with a consistent bundle branch block (BBB) defined as a QRS ≥ 120 ms, who had a secondary prophylactic ICD implanted. Patients with congenital and ischemic heart disease (IHD) were excluded. Results: Among 701 CA-survivors who survived to discharge and received an ICD, a total of 58 (8%) were free from IHD and had BBB; 46 (79%) had LBBB, 10 (17%) had RBBB and 2 (3%) had non-specific BBB (NSBBB). The prevalence of LBBB was 7%. Pre-arrest ECG were available in 34 (59%) patients; 20 patients (59%) had LBBB, 6 (18%) had RBBB, 2 (6%) had NSBBB, 1 had (3%) incomplete LBBB, and 4 (12%) without BBB. At discharge, patients with LBBB had a significantly lower left ventricular ejection fraction (LVEF) than patients with other types of BBB, p < 0.001. During follow-up, 7 (12%) died after a median of 3.6 years (IQR: 2.6–5.1) with no difference between BBB subtypes. Conclusion: We identified 58 CA-survivors with BBB and no IHD. The prevalence of LBBB among all CA-survivors was high, 7%. During CA hospitalization LBBB patients presented with a significantly lower LVEF than patients with other types of BBB (P < 0.001). ICD treatment and mortality did not differ between BBB subtypes during follow-up.
KW - Bundle Branch Block (BBB)
KW - Implantable Cardioverter Defibrillator (ICD)
KW - Sudden Cardiac Arrest (SCA)
U2 - 10.1016/j.ijcha.2023.101188
DO - 10.1016/j.ijcha.2023.101188
M3 - Journal article
C2 - 36896255
AN - SCOPUS:85149231074
VL - 45
JO - IJC Heart and Vasculature
JF - IJC Heart and Vasculature
SN - 2352-9067
M1 - 101188
ER -
ID: 339328506