Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS)
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Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS). / Heinsvig, Pia Johansson; Noble, Carolina; Dalsgaard, Petur Weihe; Mardal, Marie.
In: TrAC - Trends in Analytical Chemistry, Vol. 162, 117023, 2023.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Forensic drug screening by liquid chromatography hyphenated with high-resolution mass spectrometry (LC-HRMS)
AU - Heinsvig, Pia Johansson
AU - Noble, Carolina
AU - Dalsgaard, Petur Weihe
AU - Mardal, Marie
N1 - Funding Information: The authors would like to thank Juliet Wawira Kinyua for valuable input. PJH acknowledges Antidoping Denmark; MM acknowledges the Research Council of Norway (# 312267 ).
PY - 2023
Y1 - 2023
N2 - Liquid chromatography-high resolution mass spectrometry (LC-HRMS) has been widely used for screening small organic molecules in complex samples. Its selectivity and sensitivity allow for broad-scope screening of thousands of analytes. However, the complexity of the acquired data has complicated its implementation in high-throughput laboratories that analyze hundreds of samples per week and require that multiple users be able to analyze the data. Forensic laboratories have managed to harvest the merits of LC-HRMS technology using robust and often leveled data analysis(/acquisition) workflows, without spending a disproportionate amount of time evaluating inconclusive or false positive identifications. This critical review describes the full analytical process of LC-HRMS-based forensic drug screening, from sample preparation to data analysis and beyond. Interesting solutions are highlighted, and two emerging trends will be discussed: i) the use of free online tools to improve forensic drug screening, and ii) re-use of data to improve forensic services.
AB - Liquid chromatography-high resolution mass spectrometry (LC-HRMS) has been widely used for screening small organic molecules in complex samples. Its selectivity and sensitivity allow for broad-scope screening of thousands of analytes. However, the complexity of the acquired data has complicated its implementation in high-throughput laboratories that analyze hundreds of samples per week and require that multiple users be able to analyze the data. Forensic laboratories have managed to harvest the merits of LC-HRMS technology using robust and often leveled data analysis(/acquisition) workflows, without spending a disproportionate amount of time evaluating inconclusive or false positive identifications. This critical review describes the full analytical process of LC-HRMS-based forensic drug screening, from sample preparation to data analysis and beyond. Interesting solutions are highlighted, and two emerging trends will be discussed: i) the use of free online tools to improve forensic drug screening, and ii) re-use of data to improve forensic services.
KW - Broad-scope screening
KW - Drug screening
KW - Forensic toxicology
KW - LC-HRMS
KW - New psychoactive substances
KW - Retrospective data analysis
KW - Wide-scope screening
U2 - 10.1016/j.trac.2023.117023
DO - 10.1016/j.trac.2023.117023
M3 - Review
AN - SCOPUS:85150463353
VL - 162
JO - Trends in Analytical Chemistry
JF - Trends in Analytical Chemistry
SN - 0165-9936
M1 - 117023
ER -
ID: 341260546