Identification of the mononuclear cell infiltrate in the superior cervical ganglion of athymic nude and euthymic rats after guanethidine-induced sympathectomy
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Guanethidine sulphate 40 mg/kg intraperitoneally for 14 days induced chromatolysis and nerve cell death in the superior cervical ganglia of athymic nude (rnu/rnu) LEW/Mol rats and their euthymic (+/rnu) LEW/Mol heterozygous littermates. Histologically the sympathetic ganglia were dominated by an infiltration of small inflammatory cells. By means of monoclonal antibodies these cells were identified. The number of B-lymphocytes increased following guanethidine in both athymic and euthymic rats. The number of T-lymphocytes increased to a great extent in euthymic rats, but was virtually missing in athymic rats. The number of NK-cells and monocytes/macrophages increased in both athymic and euthymic rats. The conclusion is, that guanethidine exerts a direct effect on sympathetic ganglion cells followed by a thymus-independent immune response.
| Original language | English |
|---|---|
| Journal | International Journal of Immunopharmacology |
| Volume | 12 |
| Issue number | 3 |
| Pages (from-to) | 327-30 |
| Number of pages | 4 |
| ISSN | 0192-0561 |
| Publication status | Published - 1990 |
- Animals, Antibodies, Monoclonal, B-Lymphocytes, Body Weight, Cell Count, Ganglia, Sympathetic, Guanethidine, Immunoenzyme Techniques, Killer Cells, Natural, Leukocytes, Mononuclear, Male, Organ Size, Rats, Rats, Mutant Strains, Rats, Nude, Spleen, Sympathectomy, Chemical
Research areas
ID: 44514488