Kinetics of small lymphocytes in normal and nude mice after splenectomy

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Standard

Kinetics of small lymphocytes in normal and nude mice after splenectomy. / Hougen, H P; Hansen, F; Jensen, E K; Röpke, C.

In: Scandinavian Journal of Haematology, Vol. 18, No. 4, 04.1977, p. 257-66.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hougen, HP, Hansen, F, Jensen, EK & Röpke, C 1977, 'Kinetics of small lymphocytes in normal and nude mice after splenectomy', Scandinavian Journal of Haematology, vol. 18, no. 4, pp. 257-66.

APA

Hougen, H. P., Hansen, F., Jensen, E. K., & Röpke, C. (1977). Kinetics of small lymphocytes in normal and nude mice after splenectomy. Scandinavian Journal of Haematology, 18(4), 257-66.

Vancouver

Hougen HP, Hansen F, Jensen EK, Röpke C. Kinetics of small lymphocytes in normal and nude mice after splenectomy. Scandinavian Journal of Haematology. 1977 Apr;18(4):257-66.

Author

Hougen, H P ; Hansen, F ; Jensen, E K ; Röpke, C. / Kinetics of small lymphocytes in normal and nude mice after splenectomy. In: Scandinavian Journal of Haematology. 1977 ; Vol. 18, No. 4. pp. 257-66.

Bibtex

@article{88ef58f13665488c951eb84a0c26ecbf,
title = "Kinetics of small lymphocytes in normal and nude mice after splenectomy",
abstract = "Autoradiography and various quantitations on lymphoid tissues have been used to evaluate the kinetics of small lymphocytes in normal (+/nu or +/+) and congenitally athymic nude (nu/nu) NMRI mice 1 month after splenectomy or sham-splenectomy. The results indicate that splenectomy causes depressed thymic activity and diminished numbers of T lymphocytes in peripheral lymphoid tissues. The total number of cells in these tissues as well as the blast cell activity, were within normal limits. Bone marrow lymphocyte numbers and kinetics as well as blood lymphocyte levels in splenectomized and sham-splenectomized normal animals were comparable. Blood lymphocyte numbers were at normal levels in splenectomized nude mice, in spite of reduced numbers of bone marrow and thoracic duct lymphocytes. It is suggested that increased number of newly-formed lymphocytes, found in lymph nodes and blood of splenectomized mice, are released from the lympho-myeloid organs in compensation for the loss of long-lived, thymus-derived cells.",
keywords = "Animals, Autoradiography, Bone Marrow, Bone Marrow Cells, Cytotoxicity Tests, Immunologic, Leukocyte Count, Lymph Nodes, Lymphocytes, Mice, Mice, Nude, Scintillation Counting, Splenectomy, Thymus Gland",
author = "Hougen, {H P} and F Hansen and Jensen, {E K} and C R{\"o}pke",
year = "1977",
month = apr,
language = "English",
volume = "18",
pages = "257--66",
journal = "Scandinavian Journal of Haematology",
issn = "0036-553X",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Kinetics of small lymphocytes in normal and nude mice after splenectomy

AU - Hougen, H P

AU - Hansen, F

AU - Jensen, E K

AU - Röpke, C

PY - 1977/4

Y1 - 1977/4

N2 - Autoradiography and various quantitations on lymphoid tissues have been used to evaluate the kinetics of small lymphocytes in normal (+/nu or +/+) and congenitally athymic nude (nu/nu) NMRI mice 1 month after splenectomy or sham-splenectomy. The results indicate that splenectomy causes depressed thymic activity and diminished numbers of T lymphocytes in peripheral lymphoid tissues. The total number of cells in these tissues as well as the blast cell activity, were within normal limits. Bone marrow lymphocyte numbers and kinetics as well as blood lymphocyte levels in splenectomized and sham-splenectomized normal animals were comparable. Blood lymphocyte numbers were at normal levels in splenectomized nude mice, in spite of reduced numbers of bone marrow and thoracic duct lymphocytes. It is suggested that increased number of newly-formed lymphocytes, found in lymph nodes and blood of splenectomized mice, are released from the lympho-myeloid organs in compensation for the loss of long-lived, thymus-derived cells.

AB - Autoradiography and various quantitations on lymphoid tissues have been used to evaluate the kinetics of small lymphocytes in normal (+/nu or +/+) and congenitally athymic nude (nu/nu) NMRI mice 1 month after splenectomy or sham-splenectomy. The results indicate that splenectomy causes depressed thymic activity and diminished numbers of T lymphocytes in peripheral lymphoid tissues. The total number of cells in these tissues as well as the blast cell activity, were within normal limits. Bone marrow lymphocyte numbers and kinetics as well as blood lymphocyte levels in splenectomized and sham-splenectomized normal animals were comparable. Blood lymphocyte numbers were at normal levels in splenectomized nude mice, in spite of reduced numbers of bone marrow and thoracic duct lymphocytes. It is suggested that increased number of newly-formed lymphocytes, found in lymph nodes and blood of splenectomized mice, are released from the lympho-myeloid organs in compensation for the loss of long-lived, thymus-derived cells.

KW - Animals

KW - Autoradiography

KW - Bone Marrow

KW - Bone Marrow Cells

KW - Cytotoxicity Tests, Immunologic

KW - Leukocyte Count

KW - Lymph Nodes

KW - Lymphocytes

KW - Mice

KW - Mice, Nude

KW - Scintillation Counting

KW - Splenectomy

KW - Thymus Gland

M3 - Journal article

C2 - 857290

VL - 18

SP - 257

EP - 266

JO - Scandinavian Journal of Haematology

JF - Scandinavian Journal of Haematology

SN - 0036-553X

IS - 4

ER -

ID: 44522069