Small lymphocytes in peripheral lymphoid tissues of nude mice. Life-span and distribution

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Standard

Small lymphocytes in peripheral lymphoid tissues of nude mice. Life-span and distribution. / Hougen, H P; Röpke, C.

In: Clinical and Experimental Immunology, Vol. 22, No. 3, 12.1975, p. 528-38.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hougen, HP & Röpke, C 1975, 'Small lymphocytes in peripheral lymphoid tissues of nude mice. Life-span and distribution', Clinical and Experimental Immunology, vol. 22, no. 3, pp. 528-38.

APA

Hougen, H. P., & Röpke, C. (1975). Small lymphocytes in peripheral lymphoid tissues of nude mice. Life-span and distribution. Clinical and Experimental Immunology, 22(3), 528-38.

Vancouver

Hougen HP, Röpke C. Small lymphocytes in peripheral lymphoid tissues of nude mice. Life-span and distribution. Clinical and Experimental Immunology. 1975 Dec;22(3):528-38.

Author

Hougen, H P ; Röpke, C. / Small lymphocytes in peripheral lymphoid tissues of nude mice. Life-span and distribution. In: Clinical and Experimental Immunology. 1975 ; Vol. 22, No. 3. pp. 528-38.

Bibtex

@article{85cfbb56d1c042aba7e944b6833f6856,
title = "Small lymphocytes in peripheral lymphoid tissues of nude mice. Life-span and distribution",
abstract = "The distribution of small lymphocytes according to life-span in the peripheral lymphoid tissues of the mouse mutant {"}nude{"} has been studied by means of auto-radiography and scintillation counting to evaluate the localization of B lymphocytes with varying life-span. The vast majority of the lymphocytes in this congenitally athymic mouse are relatively long-lived, although few cells live for 6 weeks or more. Differences in labelling percentages of blood, spleen and lymph node lymphocytes indicated a production of lymphocytes with a short residence time in the spleen. A similar production was not seen in the lymph nodes. While the lymphocytes in the spleen were evenly distributed according to life-span, the paracortical lymphocytes in lymph nodes were found to have a generally shorter life-span than those of the cortex, in opposition to findings in normal mice. The cortical cells which were by far the most numerous in the lymph nodes seemed to be more sessile than para-cortical lymphocytes. The life-span of these latter cells are comparable to those of thoracic duct lymphocytes, and the scarcity of cells in the paracortex reflects the small number of recirculating lymphocytes in nude mice.",
keywords = "Animals, Autoradiography, Cell Survival, Leukocyte Count, Lymph Nodes, Lymphocytes, Lymphoid Tissue, Male, Mice, Mice, Nude, Spleen, Time Factors",
author = "Hougen, {H P} and C R{\"o}pke",
year = "1975",
month = dec,
language = "English",
volume = "22",
pages = "528--38",
journal = "Clinical and Experimental Immunology, Supplement",
issn = "0964-2536",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Small lymphocytes in peripheral lymphoid tissues of nude mice. Life-span and distribution

AU - Hougen, H P

AU - Röpke, C

PY - 1975/12

Y1 - 1975/12

N2 - The distribution of small lymphocytes according to life-span in the peripheral lymphoid tissues of the mouse mutant "nude" has been studied by means of auto-radiography and scintillation counting to evaluate the localization of B lymphocytes with varying life-span. The vast majority of the lymphocytes in this congenitally athymic mouse are relatively long-lived, although few cells live for 6 weeks or more. Differences in labelling percentages of blood, spleen and lymph node lymphocytes indicated a production of lymphocytes with a short residence time in the spleen. A similar production was not seen in the lymph nodes. While the lymphocytes in the spleen were evenly distributed according to life-span, the paracortical lymphocytes in lymph nodes were found to have a generally shorter life-span than those of the cortex, in opposition to findings in normal mice. The cortical cells which were by far the most numerous in the lymph nodes seemed to be more sessile than para-cortical lymphocytes. The life-span of these latter cells are comparable to those of thoracic duct lymphocytes, and the scarcity of cells in the paracortex reflects the small number of recirculating lymphocytes in nude mice.

AB - The distribution of small lymphocytes according to life-span in the peripheral lymphoid tissues of the mouse mutant "nude" has been studied by means of auto-radiography and scintillation counting to evaluate the localization of B lymphocytes with varying life-span. The vast majority of the lymphocytes in this congenitally athymic mouse are relatively long-lived, although few cells live for 6 weeks or more. Differences in labelling percentages of blood, spleen and lymph node lymphocytes indicated a production of lymphocytes with a short residence time in the spleen. A similar production was not seen in the lymph nodes. While the lymphocytes in the spleen were evenly distributed according to life-span, the paracortical lymphocytes in lymph nodes were found to have a generally shorter life-span than those of the cortex, in opposition to findings in normal mice. The cortical cells which were by far the most numerous in the lymph nodes seemed to be more sessile than para-cortical lymphocytes. The life-span of these latter cells are comparable to those of thoracic duct lymphocytes, and the scarcity of cells in the paracortex reflects the small number of recirculating lymphocytes in nude mice.

KW - Animals

KW - Autoradiography

KW - Cell Survival

KW - Leukocyte Count

KW - Lymph Nodes

KW - Lymphocytes

KW - Lymphoid Tissue

KW - Male

KW - Mice

KW - Mice, Nude

KW - Spleen

KW - Time Factors

M3 - Journal article

C2 - 1225488

VL - 22

SP - 528

EP - 538

JO - Clinical and Experimental Immunology, Supplement

JF - Clinical and Experimental Immunology, Supplement

SN - 0964-2536

IS - 3

ER -

ID: 44522035