An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.

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An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases. / Linnet, K.; Steentoft, A.; Simonsen, Kirsten Wiese; Sabers, Anne; Hansen, Steen Holger.

I: Forensic Science International, Bind 177, Nr. 2-3, 2008, s. 248-251.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Linnet, K, Steentoft, A, Simonsen, KW, Sabers, A & Hansen, SH 2008, 'An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.', Forensic Science International, bind 177, nr. 2-3, s. 248-251. https://doi.org/10.1016/j.forsciint.2007.10.002

APA

Linnet, K., Steentoft, A., Simonsen, K. W., Sabers, A., & Hansen, S. H. (2008). An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases. Forensic Science International, 177(2-3), 248-251. https://doi.org/10.1016/j.forsciint.2007.10.002

Vancouver

Linnet K, Steentoft A, Simonsen KW, Sabers A, Hansen SH. An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases. Forensic Science International. 2008;177(2-3):248-251. https://doi.org/10.1016/j.forsciint.2007.10.002

Author

Linnet, K. ; Steentoft, A. ; Simonsen, Kirsten Wiese ; Sabers, Anne ; Hansen, Steen Holger. / An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases. I: Forensic Science International. 2008 ; Bind 177, Nr. 2-3. s. 248-251.

Bibtex

@article{ae7b1370f11d11ddbf70000ea68e967b,
title = "An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.",
abstract = "We present an oxcarbazepine-related fatality together with an overview of 26 postmortem cases involving oxcarbazepine observed during the period 2001-2006. The fatality case concerned a 27-year-old woman with epilepsy, who was found dead in her bed. Oxcarbazepine and its active metabolite, 10-hydroxycarbazepine, were the only compounds detected. The concentrations of oxcarbazepine were as follows: femoral blood, 2.9 mg/kg; muscle, 1.8 mg/kg; liver, 0.9 mg/kg; gastric content (300 ml), 860 mg/kg; and vitreous humour, not detected. The concentrations of 10-hydroxycarbazepine were as follows: femoral blood, 66 mg/kg; muscle, 40 mg/kg; liver, 62 mg/kg; gastric content, 27 mg/kg; and vitreous humour, 25 mg/kg. The analyses were performed by HPLC-DAD after liquid-liquid extraction. Oxcarbazepine intoxication was regarded as a possible cause of death. For the other 26 cases, the 10-hydroxycarbazepine concentrations ranged from 2.2 to 48 mg/kg with a median of 25 mg/kg.",
author = "K. Linnet and A. Steentoft and Simonsen, {Kirsten Wiese} and Anne Sabers and Hansen, {Steen Holger}",
year = "2008",
doi = "10.1016/j.forsciint.2007.10.002",
language = "English",
volume = "177",
pages = "248--251",
journal = "Forensic Science International",
issn = "0379-0738",
publisher = "Elsevier Ireland Ltd",
number = "2-3",

}

RIS

TY - JOUR

T1 - An oxcarbazepine-related fatality with an overview of 26 oxcarbazepine postmortem cases.

AU - Linnet, K.

AU - Steentoft, A.

AU - Simonsen, Kirsten Wiese

AU - Sabers, Anne

AU - Hansen, Steen Holger

PY - 2008

Y1 - 2008

N2 - We present an oxcarbazepine-related fatality together with an overview of 26 postmortem cases involving oxcarbazepine observed during the period 2001-2006. The fatality case concerned a 27-year-old woman with epilepsy, who was found dead in her bed. Oxcarbazepine and its active metabolite, 10-hydroxycarbazepine, were the only compounds detected. The concentrations of oxcarbazepine were as follows: femoral blood, 2.9 mg/kg; muscle, 1.8 mg/kg; liver, 0.9 mg/kg; gastric content (300 ml), 860 mg/kg; and vitreous humour, not detected. The concentrations of 10-hydroxycarbazepine were as follows: femoral blood, 66 mg/kg; muscle, 40 mg/kg; liver, 62 mg/kg; gastric content, 27 mg/kg; and vitreous humour, 25 mg/kg. The analyses were performed by HPLC-DAD after liquid-liquid extraction. Oxcarbazepine intoxication was regarded as a possible cause of death. For the other 26 cases, the 10-hydroxycarbazepine concentrations ranged from 2.2 to 48 mg/kg with a median of 25 mg/kg.

AB - We present an oxcarbazepine-related fatality together with an overview of 26 postmortem cases involving oxcarbazepine observed during the period 2001-2006. The fatality case concerned a 27-year-old woman with epilepsy, who was found dead in her bed. Oxcarbazepine and its active metabolite, 10-hydroxycarbazepine, were the only compounds detected. The concentrations of oxcarbazepine were as follows: femoral blood, 2.9 mg/kg; muscle, 1.8 mg/kg; liver, 0.9 mg/kg; gastric content (300 ml), 860 mg/kg; and vitreous humour, not detected. The concentrations of 10-hydroxycarbazepine were as follows: femoral blood, 66 mg/kg; muscle, 40 mg/kg; liver, 62 mg/kg; gastric content, 27 mg/kg; and vitreous humour, 25 mg/kg. The analyses were performed by HPLC-DAD after liquid-liquid extraction. Oxcarbazepine intoxication was regarded as a possible cause of death. For the other 26 cases, the 10-hydroxycarbazepine concentrations ranged from 2.2 to 48 mg/kg with a median of 25 mg/kg.

U2 - 10.1016/j.forsciint.2007.10.002

DO - 10.1016/j.forsciint.2007.10.002

M3 - Journal article

C2 - 18036757

VL - 177

SP - 248

EP - 251

JO - Forensic Science International

JF - Forensic Science International

SN - 0379-0738

IS - 2-3

ER -

ID: 10091819