Calcium and vitamin D3 supplements in calcium and vitamin D3 sufficient early postmenopausal healthy women
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Objective: To study the calcium homeostasis in healthy, calcium and vitamin D replete early postmenopausal women during oral supplementation with calcium and vitamin D3. Design: A prospective, placebo-controlled, randomised, double-single-blind, 3-week study. Setting: Outpatient clinic at Copenhagen University Hospital, Denmark. Subjects: In all, 17 started, one was excluded. Totally, 16 healthy women, 45-61 y of age (mean 57.3 y) who were at least 4 y after menopause (mean 6.7 y) completed. Interventions: All underwent three consecutive 7-day study periods. Each began with 4 days of normal diet followed by 3 days treatment of either C: one tablet of 1.250 mg calcium carbonate (ie 500 mg Ca2+ per tablet) twice daily (breakfast and dinner), or CD3: as in C but plus 400 IU vitamin D3 b.i.d., or P (only) placebo tablets b.i.d. Results: At baseline plasma 25-hydroxycholecalciferol was normal (66±22 nmol/l) and the calcium intake without supplements 850 mg/day. In group C, the 24-h urinary calcium increased by 35% (6.9±2.0 mmol), vs the placebo group P (5.1±1.6 mmol) (P<0.05). Addition of 800 IU vitamin D3 daily (CD3) did not increase calcium excretion further (6.6±2.1 mmol) but decreased plasma 1,25-(OH 2-vitamin D3 by 21% (P<0.05). Conclusions: In this carefully controlled study calcium plus vitamin D3 supplements only had minor influences of uncertain significance on the calcium balance in healthy, calcium and vitamin D sufficient early postmenopausal women.
Originalsprog | Engelsk |
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Tidsskrift | European Journal of Clinical Nutrition |
Vol/bind | 58 |
Udgave nummer | 10 |
Sider (fra-til) | 1420-1424 |
Antal sider | 5 |
ISSN | 0954-3007 |
DOI | |
Status | Udgivet - 1 okt. 2004 |
Eksternt udgivet | Ja |
ID: 203877319