Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC–QTOF-MS

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Standard

Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC–QTOF-MS. / Hansen, Stine Lund; Dalsgaard, Petur Weihe; Linnet, Kristian; Rasmussen, Brian Schou.

I: Journal of Analytical Toxicology, Bind 46, Nr. 9, 2022, s. 1053–1058.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hansen, SL, Dalsgaard, PW, Linnet, K & Rasmussen, BS 2022, 'Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC–QTOF-MS', Journal of Analytical Toxicology, bind 46, nr. 9, s. 1053–1058. https://doi.org/10.1093/jat/bkac011

APA

Hansen, S. L., Dalsgaard, P. W., Linnet, K., & Rasmussen, B. S. (2022). Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC–QTOF-MS. Journal of Analytical Toxicology, 46(9), 1053–1058. https://doi.org/10.1093/jat/bkac011

Vancouver

Hansen SL, Dalsgaard PW, Linnet K, Rasmussen BS. Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC–QTOF-MS. Journal of Analytical Toxicology. 2022;46(9):1053–1058. https://doi.org/10.1093/jat/bkac011

Author

Hansen, Stine Lund ; Dalsgaard, Petur Weihe ; Linnet, Kristian ; Rasmussen, Brian Schou. / Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC–QTOF-MS. I: Journal of Analytical Toxicology. 2022 ; Bind 46, Nr. 9. s. 1053–1058.

Bibtex

@article{266e2a670fea4aca9702f0d51b0e7104,
title = "Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC–QTOF-MS",
abstract = "Alternative specimens collected during autopsies can be valuable in postmortem toxicology in cases where peripheral blood is not available. The applicability of brain tissue as an alternative matrix for drug screening by ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry was investigated in this study. Results of the 50 most frequently detected drugs and metabolites of toxicological interest in blood and brain tissue samples from 1,719 autopsy cases were compared. Examination of the results in paired blood and brain tissue samples revealed that the two matrices were in general comparable, as the majority of the 50 analytes were observed in a high number of the examined cases in both blood and brain tissue. This demonstrates the potential of brain tissue as an alternative matrix for drug screening in postmortem toxicology or as a secondary matrix for confirmation.",
author = "Hansen, {Stine Lund} and Dalsgaard, {Petur Weihe} and Kristian Linnet and Rasmussen, {Brian Schou}",
year = "2022",
doi = "10.1093/jat/bkac011",
language = "English",
volume = "46",
pages = "1053–1058",
journal = "Journal of Analytical Toxicology",
issn = "0146-4760",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Comparison of Comprehensive Screening Results in Postmortem Blood and Brain Tissue by UHPLC–QTOF-MS

AU - Hansen, Stine Lund

AU - Dalsgaard, Petur Weihe

AU - Linnet, Kristian

AU - Rasmussen, Brian Schou

PY - 2022

Y1 - 2022

N2 - Alternative specimens collected during autopsies can be valuable in postmortem toxicology in cases where peripheral blood is not available. The applicability of brain tissue as an alternative matrix for drug screening by ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry was investigated in this study. Results of the 50 most frequently detected drugs and metabolites of toxicological interest in blood and brain tissue samples from 1,719 autopsy cases were compared. Examination of the results in paired blood and brain tissue samples revealed that the two matrices were in general comparable, as the majority of the 50 analytes were observed in a high number of the examined cases in both blood and brain tissue. This demonstrates the potential of brain tissue as an alternative matrix for drug screening in postmortem toxicology or as a secondary matrix for confirmation.

AB - Alternative specimens collected during autopsies can be valuable in postmortem toxicology in cases where peripheral blood is not available. The applicability of brain tissue as an alternative matrix for drug screening by ultra-high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry was investigated in this study. Results of the 50 most frequently detected drugs and metabolites of toxicological interest in blood and brain tissue samples from 1,719 autopsy cases were compared. Examination of the results in paired blood and brain tissue samples revealed that the two matrices were in general comparable, as the majority of the 50 analytes were observed in a high number of the examined cases in both blood and brain tissue. This demonstrates the potential of brain tissue as an alternative matrix for drug screening in postmortem toxicology or as a secondary matrix for confirmation.

U2 - 10.1093/jat/bkac011

DO - 10.1093/jat/bkac011

M3 - Journal article

C2 - 35157763

VL - 46

SP - 1053

EP - 1058

JO - Journal of Analytical Toxicology

JF - Journal of Analytical Toxicology

SN - 0146-4760

IS - 9

ER -

ID: 309197934