TY - JOUR

T1 - Diagnostic values of fasting and postprandial concentrations in serum of 3αhydroxy-bile acids and gamma-glutamyl transferase in hepatobiliary disease

AU - Linnet, K.

AU - Kelbæk, H.

AU - Bahnsen, M.

PY - 1983/1/1

Y1 - 1983/1/1

N2 - Fasting and postprandial concentrations in serum of 3αhydroxy-bile acids and gamma-glutamyl transferase were measured in 138 consecutive patients, 62 with (D) and 76 without (D) hepatobiliary disease. The maximum efficiencies of the three tests - that is, the fractions of patients allocated correctly to the D or D group at the optimum discrimination values - were 0.85, 0.84, and 0.83, respectively. Furthermore, the predictive values and nosographic sensitivities and specificities were rather similar. When the three tests were combined, the nosographic sensitivity increased significantly to a value of 0.84, and the corresponding specificity was 0.91. The diagnostic value of the absolute postprandial increase in serum bile acid concentration was slightly inferior to the diagnostic values of the fasting and postprandial serum bile acid concentrations and, finally, the relative postprandial serum bile acid increase was of no diagnostic value at all.

AB - Fasting and postprandial concentrations in serum of 3αhydroxy-bile acids and gamma-glutamyl transferase were measured in 138 consecutive patients, 62 with (D) and 76 without (D) hepatobiliary disease. The maximum efficiencies of the three tests - that is, the fractions of patients allocated correctly to the D or D group at the optimum discrimination values - were 0.85, 0.84, and 0.83, respectively. Furthermore, the predictive values and nosographic sensitivities and specificities were rather similar. When the three tests were combined, the nosographic sensitivity increased significantly to a value of 0.84, and the corresponding specificity was 0.91. The diagnostic value of the absolute postprandial increase in serum bile acid concentration was slightly inferior to the diagnostic values of the fasting and postprandial serum bile acid concentrations and, finally, the relative postprandial serum bile acid increase was of no diagnostic value at all.

KW - 3αhydroxy-bile acids

KW - Diagnosis

KW - Gamma-glutamyl transferase

KW - Hepatobiliary disease

KW - Serum

UR - http://www.scopus.com/inward/record.url?scp=0020671683&partnerID=8YFLogxK

U2 - 10.3109/00365528309181558

DO - 10.3109/00365528309181558

M3 - Journal article

C2 - 6144169

AN - SCOPUS:0020671683

VL - 18

SP - 49

EP - 56

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 1

ER -