Glycine‐modified growth hormone secretagogues identified in seized doping material

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Standard

Glycine‐modified growth hormone secretagogues identified in seized doping material. / Gajda, Paulina Marta; Holm, Niels Bjerre; Hoej, Lars Jakobsen; Rasmussen, Brian Schou; Dalsgaard, Petur Weihe; Reitzel, Lotte Ask; Linnet, Kristian.

I: Drug Testing and Analysis, Bind 11, Nr. 2, 02.2019, s. 350-354.

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Harvard

Gajda, PM, Holm, NB, Hoej, LJ, Rasmussen, BS, Dalsgaard, PW, Reitzel, LA & Linnet, K 2019, 'Glycine‐modified growth hormone secretagogues identified in seized doping material', Drug Testing and Analysis, bind 11, nr. 2, s. 350-354. https://doi.org/10.1002/dta.2489

APA

Gajda, P. M., Holm, N. B., Hoej, L. J., Rasmussen, B. S., Dalsgaard, P. W., Reitzel, L. A., & Linnet, K. (2019). Glycine‐modified growth hormone secretagogues identified in seized doping material. Drug Testing and Analysis, 11(2), 350-354. https://doi.org/10.1002/dta.2489

Vancouver

Gajda PM, Holm NB, Hoej LJ, Rasmussen BS, Dalsgaard PW, Reitzel LA o.a. Glycine‐modified growth hormone secretagogues identified in seized doping material. Drug Testing and Analysis. 2019 feb.;11(2):350-354. https://doi.org/10.1002/dta.2489

Author

Gajda, Paulina Marta ; Holm, Niels Bjerre ; Hoej, Lars Jakobsen ; Rasmussen, Brian Schou ; Dalsgaard, Petur Weihe ; Reitzel, Lotte Ask ; Linnet, Kristian. / Glycine‐modified growth hormone secretagogues identified in seized doping material. I: Drug Testing and Analysis. 2019 ; Bind 11, Nr. 2. s. 350-354.

Bibtex

@article{bda7d1c1054245a2a6332c1c179f81f4,
title = "Glycine‐modified growth hormone secretagogues identified in seized doping material",
abstract = "A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.",
keywords = "doping, growth hormone secretagogues, LC–MS, modified GRF 1–29, Peptide hormones",
author = "Gajda, {Paulina Marta} and Holm, {Niels Bjerre} and Hoej, {Lars Jakobsen} and Rasmussen, {Brian Schou} and Dalsgaard, {Petur Weihe} and Reitzel, {Lotte Ask} and Kristian Linnet",
year = "2019",
month = feb,
doi = "10.1002/dta.2489",
language = "English",
volume = "11",
pages = "350--354",
journal = "Drug Testing and Analysis",
issn = "1942-7603",
publisher = "JohnWiley & Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Glycine‐modified growth hormone secretagogues identified in seized doping material

AU - Gajda, Paulina Marta

AU - Holm, Niels Bjerre

AU - Hoej, Lars Jakobsen

AU - Rasmussen, Brian Schou

AU - Dalsgaard, Petur Weihe

AU - Reitzel, Lotte Ask

AU - Linnet, Kristian

PY - 2019/2

Y1 - 2019/2

N2 - A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.

AB - A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography–high resolution mass spectrometry (LC–HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1–29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.

KW - doping

KW - growth hormone secretagogues

KW - LC–MS

KW - modified GRF 1–29

KW - Peptide hormones

UR - http://www.scopus.com/inward/record.url?scp=85053388656&partnerID=8YFLogxK

U2 - 10.1002/dta.2489

DO - 10.1002/dta.2489

M3 - Letter

C2 - 30136411

AN - SCOPUS:85053388656

VL - 11

SP - 350

EP - 354

JO - Drug Testing and Analysis

JF - Drug Testing and Analysis

SN - 1942-7603

IS - 2

ER -

ID: 203562668