Hair cortisol concentrations in decedents with severe mental illness – An autopsy-based cohort study
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Hair cortisol concentrations in decedents with severe mental illness – An autopsy-based cohort study. / Busch, Johannes Rødbro; Wang, Xin; Lynnerup, Niels; Jacobsen, Christina; Jørgensen, Martin Balslev; Linnet, Kristian; Johansen, Sys Stybe; Banner, Jytte.
I: Forensic Science International: Reports, Bind 3, 100173, 07.2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Hair cortisol concentrations in decedents with severe mental illness – An autopsy-based cohort study
AU - Busch, Johannes Rødbro
AU - Wang, Xin
AU - Lynnerup, Niels
AU - Jacobsen, Christina
AU - Jørgensen, Martin Balslev
AU - Linnet, Kristian
AU - Johansen, Sys Stybe
AU - Banner, Jytte
PY - 2021/7
Y1 - 2021/7
N2 - Severe mental illness (SMI) is associated with a marked increase in mortality, both from natural and unnatural causes. Patients may be subject to accelerated aging and an increased disposition for developing chronic somatic disease. One possible contributory cause to this may be chronic hyperactivity of the hypothalamus-pituitary-adrenal (HPA)-axis and subsequent increased levels of cortisol. This study analyzed hair cortisol concentrations (HCC) using ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) in hair samples from forensic autopsies of patients with SMI, validated via health registry data. Results: HCC was not associated with a particular diagnosis or increased in patients compared with decedents without SMI. HCC was higher in decedents who had been prescribed psychotropic medication, especially SSRI and benzodiazepines. HCC was not associated with a history of coerced admissions or high number of days of admission. Future studies evaluating HCC as a proxy marker for stress should consider including medication history as a covariate. Reference ranges for healthy adults using standardized methods are needed in order to provide better interpretation of patient HCC.
AB - Severe mental illness (SMI) is associated with a marked increase in mortality, both from natural and unnatural causes. Patients may be subject to accelerated aging and an increased disposition for developing chronic somatic disease. One possible contributory cause to this may be chronic hyperactivity of the hypothalamus-pituitary-adrenal (HPA)-axis and subsequent increased levels of cortisol. This study analyzed hair cortisol concentrations (HCC) using ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) in hair samples from forensic autopsies of patients with SMI, validated via health registry data. Results: HCC was not associated with a particular diagnosis or increased in patients compared with decedents without SMI. HCC was higher in decedents who had been prescribed psychotropic medication, especially SSRI and benzodiazepines. HCC was not associated with a history of coerced admissions or high number of days of admission. Future studies evaluating HCC as a proxy marker for stress should consider including medication history as a covariate. Reference ranges for healthy adults using standardized methods are needed in order to provide better interpretation of patient HCC.
KW - Forensic autopsy
KW - Hair cortisol
KW - Physiological hypercortisolemia
KW - Schizophrenia
KW - Severe mental illness
UR - http://www.scopus.com/inward/record.url?scp=85100205109&partnerID=8YFLogxK
U2 - 10.1016/j.fsir.2021.100173
DO - 10.1016/j.fsir.2021.100173
M3 - Journal article
AN - SCOPUS:85100205109
VL - 3
JO - Forensic Science International: Reports
JF - Forensic Science International: Reports
SN - 2665-9107
M1 - 100173
ER -
ID: 256514163