Postmortem Blood Concentrations of R- and S-Enantiomers of Methadone and EDDP in Drug Users: Influence of Co-Medication and P-glycoprotein Genotype

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Standard

Postmortem Blood Concentrations of R- and S-Enantiomers of Methadone and EDDP in Drug Users: Influence of Co-Medication and P-glycoprotein Genotype. / Buchard, Anders; Linnet, Kristian; Johansen, Sys Stybe; Munkholm, Julie; Fregerslev, Michael; Morling, Niels.

I: Journal of Forensic Sciences, Bind 55, Nr. 2, 2010, s. 457-63.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Buchard, A, Linnet, K, Johansen, SS, Munkholm, J, Fregerslev, M & Morling, N 2010, 'Postmortem Blood Concentrations of R- and S-Enantiomers of Methadone and EDDP in Drug Users: Influence of Co-Medication and P-glycoprotein Genotype', Journal of Forensic Sciences, bind 55, nr. 2, s. 457-63. https://doi.org/10.1111/j.1556-4029.2009.01278.x

APA

Buchard, A., Linnet, K., Johansen, S. S., Munkholm, J., Fregerslev, M., & Morling, N. (2010). Postmortem Blood Concentrations of R- and S-Enantiomers of Methadone and EDDP in Drug Users: Influence of Co-Medication and P-glycoprotein Genotype. Journal of Forensic Sciences, 55(2), 457-63. https://doi.org/10.1111/j.1556-4029.2009.01278.x

Vancouver

Buchard A, Linnet K, Johansen SS, Munkholm J, Fregerslev M, Morling N. Postmortem Blood Concentrations of R- and S-Enantiomers of Methadone and EDDP in Drug Users: Influence of Co-Medication and P-glycoprotein Genotype. Journal of Forensic Sciences. 2010;55(2):457-63. https://doi.org/10.1111/j.1556-4029.2009.01278.x

Author

Buchard, Anders ; Linnet, Kristian ; Johansen, Sys Stybe ; Munkholm, Julie ; Fregerslev, Michael ; Morling, Niels. / Postmortem Blood Concentrations of R- and S-Enantiomers of Methadone and EDDP in Drug Users: Influence of Co-Medication and P-glycoprotein Genotype. I: Journal of Forensic Sciences. 2010 ; Bind 55, Nr. 2. s. 457-63.

Bibtex

@article{d1785090328011df8ed1000ea68e967b,
title = "Postmortem Blood Concentrations of R- and S-Enantiomers of Methadone and EDDP in Drug Users: Influence of Co-Medication and P-glycoprotein Genotype",
abstract = "We investigated toxicological and pharmacogenetic factors that could influence methadone toxicity using postmortem samples. R- and S-methadone were measured in femoral blood from 90 postmortem cases, mainly drug users. The R-enantiomer concentrations significantly exceeded that of the S-enantiomers (Wilcoxon's test, p < 0.001). The samples were divided into four groups according to other drugs detected (methadone only, methadone and strong analgesics, methadone and benzodiazepines, or methadone and other drugs). There was no significant difference in any of the R-methadone/total methadone ratios among the four groups. The median R/S ratio was 1.38, which tends to be higher than that reported for the plasma of living subjects. In addition, we investigated whether small nucleotide polymorphisms in the MDR1 gene that encode the drug transporter P-glycoprotein were associated with the concentrations of R- and S-methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine. No significant association was detected.",
author = "Anders Buchard and Kristian Linnet and Johansen, {Sys Stybe} and Julie Munkholm and Michael Fregerslev and Niels Morling",
year = "2010",
doi = "10.1111/j.1556-4029.2009.01278.x",
language = "English",
volume = "55",
pages = "457--63",
journal = "Journal of Forensic Sciences",
issn = "0022-1198",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Postmortem Blood Concentrations of R- and S-Enantiomers of Methadone and EDDP in Drug Users: Influence of Co-Medication and P-glycoprotein Genotype

AU - Buchard, Anders

AU - Linnet, Kristian

AU - Johansen, Sys Stybe

AU - Munkholm, Julie

AU - Fregerslev, Michael

AU - Morling, Niels

PY - 2010

Y1 - 2010

N2 - We investigated toxicological and pharmacogenetic factors that could influence methadone toxicity using postmortem samples. R- and S-methadone were measured in femoral blood from 90 postmortem cases, mainly drug users. The R-enantiomer concentrations significantly exceeded that of the S-enantiomers (Wilcoxon's test, p < 0.001). The samples were divided into four groups according to other drugs detected (methadone only, methadone and strong analgesics, methadone and benzodiazepines, or methadone and other drugs). There was no significant difference in any of the R-methadone/total methadone ratios among the four groups. The median R/S ratio was 1.38, which tends to be higher than that reported for the plasma of living subjects. In addition, we investigated whether small nucleotide polymorphisms in the MDR1 gene that encode the drug transporter P-glycoprotein were associated with the concentrations of R- and S-methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine. No significant association was detected.

AB - We investigated toxicological and pharmacogenetic factors that could influence methadone toxicity using postmortem samples. R- and S-methadone were measured in femoral blood from 90 postmortem cases, mainly drug users. The R-enantiomer concentrations significantly exceeded that of the S-enantiomers (Wilcoxon's test, p < 0.001). The samples were divided into four groups according to other drugs detected (methadone only, methadone and strong analgesics, methadone and benzodiazepines, or methadone and other drugs). There was no significant difference in any of the R-methadone/total methadone ratios among the four groups. The median R/S ratio was 1.38, which tends to be higher than that reported for the plasma of living subjects. In addition, we investigated whether small nucleotide polymorphisms in the MDR1 gene that encode the drug transporter P-glycoprotein were associated with the concentrations of R- and S-methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine. No significant association was detected.

U2 - 10.1111/j.1556-4029.2009.01278.x

DO - 10.1111/j.1556-4029.2009.01278.x

M3 - Journal article

C2 - 20102450

VL - 55

SP - 457

EP - 463

JO - Journal of Forensic Sciences

JF - Journal of Forensic Sciences

SN - 0022-1198

IS - 2

ER -

ID: 18692240