Predictive value of the concentration in serum of total 3αhydroxy bile acids in the diagnosis of hepatobiliary disease

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Standard

Predictive value of the concentration in serum of total 3αhydroxy bile acids in the diagnosis of hepatobiliary disease. / Linnet, K.; Kelbák, H.

I: Scandinavian Journal of Gastroenterology, Bind 17, Nr. 2, 01.01.1982, s. 263-268.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Linnet, K & Kelbák, H 1982, 'Predictive value of the concentration in serum of total 3αhydroxy bile acids in the diagnosis of hepatobiliary disease', Scandinavian Journal of Gastroenterology, bind 17, nr. 2, s. 263-268. https://doi.org/10.3109/00365528209182050

APA

Linnet, K., & Kelbák, H. (1982). Predictive value of the concentration in serum of total 3αhydroxy bile acids in the diagnosis of hepatobiliary disease. Scandinavian Journal of Gastroenterology, 17(2), 263-268. https://doi.org/10.3109/00365528209182050

Vancouver

Linnet K, Kelbák H. Predictive value of the concentration in serum of total 3αhydroxy bile acids in the diagnosis of hepatobiliary disease. Scandinavian Journal of Gastroenterology. 1982 jan. 1;17(2):263-268. https://doi.org/10.3109/00365528209182050

Author

Linnet, K. ; Kelbák, H. / Predictive value of the concentration in serum of total 3αhydroxy bile acids in the diagnosis of hepatobiliary disease. I: Scandinavian Journal of Gastroenterology. 1982 ; Bind 17, Nr. 2. s. 263-268.

Bibtex

@article{4a065a5f662d4d7d9042b857c1041a0c,
title = "Predictive value of the concentration in serum of total 3αhydroxy bile acids in the diagnosis of hepatobiliary disease",
abstract = "Fasting serum levels of total 3αhydroxy bile acids were measured in 163 consecutive patients, who clinically were suspected of having a hepatobiliary disorder. By means of routine biochemical liver tests and paraclinical investigations the clinical suspicion was confirmed in 95 patients and disproved in the other 68 patients. A comparison between this diagnostic grouping and the serum bile acids levels showed that the predictive value of serum concentrations above a discrimination value of 10 μmol/l - that is, the predictive value of a positive test - was 1.0 (0.94-1.0), whereas the corresponding predictive value of a negative test was 0.66 (0.56-0.75). Thus, fasting serum levels of total 3αhydroxy bile acids may be used as a highly specific and moderately sensitive diagnostic test for hepatobiliary disorders. Furthermore, the study showed that the nosographic sensitivity of total 3αhydroxy bile acids in patients with verified cirrhosis was significantly greater than that of serum bilirubins and not significantly different from those of the other routine biochemical liver tests.",
keywords = "Hepatobiliary disease, Predictive values, Serum bile acids",
author = "K. Linnet and H. Kelb{\'a}k",
year = "1982",
month = jan,
day = "1",
doi = "10.3109/00365528209182050",
language = "English",
volume = "17",
pages = "263--268",
journal = "Scandinavian Journal of Gastroenterology. Supplement",
issn = "0085-5928",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - Predictive value of the concentration in serum of total 3αhydroxy bile acids in the diagnosis of hepatobiliary disease

AU - Linnet, K.

AU - Kelbák, H.

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Fasting serum levels of total 3αhydroxy bile acids were measured in 163 consecutive patients, who clinically were suspected of having a hepatobiliary disorder. By means of routine biochemical liver tests and paraclinical investigations the clinical suspicion was confirmed in 95 patients and disproved in the other 68 patients. A comparison between this diagnostic grouping and the serum bile acids levels showed that the predictive value of serum concentrations above a discrimination value of 10 μmol/l - that is, the predictive value of a positive test - was 1.0 (0.94-1.0), whereas the corresponding predictive value of a negative test was 0.66 (0.56-0.75). Thus, fasting serum levels of total 3αhydroxy bile acids may be used as a highly specific and moderately sensitive diagnostic test for hepatobiliary disorders. Furthermore, the study showed that the nosographic sensitivity of total 3αhydroxy bile acids in patients with verified cirrhosis was significantly greater than that of serum bilirubins and not significantly different from those of the other routine biochemical liver tests.

AB - Fasting serum levels of total 3αhydroxy bile acids were measured in 163 consecutive patients, who clinically were suspected of having a hepatobiliary disorder. By means of routine biochemical liver tests and paraclinical investigations the clinical suspicion was confirmed in 95 patients and disproved in the other 68 patients. A comparison between this diagnostic grouping and the serum bile acids levels showed that the predictive value of serum concentrations above a discrimination value of 10 μmol/l - that is, the predictive value of a positive test - was 1.0 (0.94-1.0), whereas the corresponding predictive value of a negative test was 0.66 (0.56-0.75). Thus, fasting serum levels of total 3αhydroxy bile acids may be used as a highly specific and moderately sensitive diagnostic test for hepatobiliary disorders. Furthermore, the study showed that the nosographic sensitivity of total 3αhydroxy bile acids in patients with verified cirrhosis was significantly greater than that of serum bilirubins and not significantly different from those of the other routine biochemical liver tests.

KW - Hepatobiliary disease

KW - Predictive values

KW - Serum bile acids

UR - http://www.scopus.com/inward/record.url?scp=0020043187&partnerID=8YFLogxK

U2 - 10.3109/00365528209182050

DO - 10.3109/00365528209182050

M3 - Journal article

C2 - 7134852

AN - SCOPUS:0020043187

VL - 17

SP - 263

EP - 268

JO - Scandinavian Journal of Gastroenterology. Supplement

JF - Scandinavian Journal of Gastroenterology. Supplement

SN - 0085-5928

IS - 2

ER -

ID: 230032137