Saffold virus infection associated with human myocarditis

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Standard

Saffold virus infection associated with human myocarditis. / Nielsen, Trine Skov; Nielsen, Alex Yde; Banner, Jytte; Hansen, Jakob; Baandrup, Ulrik; Nielsen, Lars Peter.

I: Journal of Clinical Virology, Bind 74, 01.2016, s. 78-81.

Publikation: Bidrag til tidsskrift › Letter › Forskning › fagfællebedømt

Harvard

Nielsen, TS, Nielsen, AY, Banner, J, Hansen, J, Baandrup, U & Nielsen, LP 2016, 'Saffold virus infection associated with human myocarditis', Journal of Clinical Virology, bind 74, s. 78-81. https://doi.org/10.1016/j.jcv.2015.11.028

APA

Nielsen, T. S., Nielsen, A. Y., Banner, J., Hansen, J., Baandrup, U., & Nielsen, L. P. (2016). Saffold virus infection associated with human myocarditis. Journal of Clinical Virology, 74, 78-81. https://doi.org/10.1016/j.jcv.2015.11.028

Vancouver

Nielsen TS, Nielsen AY, Banner J, Hansen J, Baandrup U, Nielsen LP. Saffold virus infection associated with human myocarditis. Journal of Clinical Virology. 2016 jan.;74:78-81. https://doi.org/10.1016/j.jcv.2015.11.028

Author

Nielsen, Trine Skov ; Nielsen, Alex Yde ; Banner, Jytte ; Hansen, Jakob ; Baandrup, Ulrik ; Nielsen, Lars Peter. / Saffold virus infection associated with human myocarditis. I: Journal of Clinical Virology. 2016 ; Bind 74. s. 78-81.

Bibtex

@article{6f964bafed4b47768241797f9a473295,

title = "Saffold virus infection associated with human myocarditis",

abstract = "BACKGROUND: Saffold virus was described in 2007 as one of the first human viruses within the genus cardioviruses. Cardioviruses may cause severe infections of the myocardium in animals, and several studies have associated saffold virus with human disease. As a result, saffold virus has been isolated from different anatomical compartments, including the myocardium, but, until now, it has not been possible to demonstrate the accompanying histopathological signs of inflammation.OBJECTIVES: The aim of the study was to examine if saffold virus is capable of causing invasive infection in the human myocardium.STUDY DESIGN: Using real-time PCR, we retrospectively examined formalin-fixed paraffin embedded cardiac tissue specimens from 150 deceased individuals diagnosed with myocarditis at autopsy. The results were compared with histological findings.RESULTS AND CONCLUSIONS: Saffold virus was detected in the myocardium, lung tissue and blood of one child and was accompanied by histopathological inflammation in the heart and lungs, which was supportive of a viral infection. These findings suggest that cardioviruses may be associated with myocarditis in humans.",

keywords = "Adolescent, Adult, Aged, Cardiovirus Infections, Child, Child, Preschool, Female, Humans, Infant, Male, Middle Aged, Myocarditis, Pathology, Molecular, Real-Time Polymerase Chain Reaction, Retrospective Studies, Theilovirus, Young Adult",

author = "Nielsen, {Trine Skov} and Nielsen, {Alex Yde} and Jytte Banner and Jakob Hansen and Ulrik Baandrup and Nielsen, {Lars Peter}",

year = "2016",

month = jan,

doi = "10.1016/j.jcv.2015.11.028",

language = "English",

volume = "74",

pages = "78--81",

journal = "Journal of Clinical Virology",

issn = "1386-6532",

publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Saffold virus infection associated with human myocarditis

AU - Nielsen, Trine Skov

AU - Nielsen, Alex Yde

AU - Banner, Jytte

AU - Hansen, Jakob

AU - Baandrup, Ulrik

AU - Nielsen, Lars Peter

PY - 2016/1

Y1 - 2016/1

N2 - BACKGROUND: Saffold virus was described in 2007 as one of the first human viruses within the genus cardioviruses. Cardioviruses may cause severe infections of the myocardium in animals, and several studies have associated saffold virus with human disease. As a result, saffold virus has been isolated from different anatomical compartments, including the myocardium, but, until now, it has not been possible to demonstrate the accompanying histopathological signs of inflammation.OBJECTIVES: The aim of the study was to examine if saffold virus is capable of causing invasive infection in the human myocardium.STUDY DESIGN: Using real-time PCR, we retrospectively examined formalin-fixed paraffin embedded cardiac tissue specimens from 150 deceased individuals diagnosed with myocarditis at autopsy. The results were compared with histological findings.RESULTS AND CONCLUSIONS: Saffold virus was detected in the myocardium, lung tissue and blood of one child and was accompanied by histopathological inflammation in the heart and lungs, which was supportive of a viral infection. These findings suggest that cardioviruses may be associated with myocarditis in humans.

AB - BACKGROUND: Saffold virus was described in 2007 as one of the first human viruses within the genus cardioviruses. Cardioviruses may cause severe infections of the myocardium in animals, and several studies have associated saffold virus with human disease. As a result, saffold virus has been isolated from different anatomical compartments, including the myocardium, but, until now, it has not been possible to demonstrate the accompanying histopathological signs of inflammation.OBJECTIVES: The aim of the study was to examine if saffold virus is capable of causing invasive infection in the human myocardium.STUDY DESIGN: Using real-time PCR, we retrospectively examined formalin-fixed paraffin embedded cardiac tissue specimens from 150 deceased individuals diagnosed with myocarditis at autopsy. The results were compared with histological findings.RESULTS AND CONCLUSIONS: Saffold virus was detected in the myocardium, lung tissue and blood of one child and was accompanied by histopathological inflammation in the heart and lungs, which was supportive of a viral infection. These findings suggest that cardioviruses may be associated with myocarditis in humans.

KW - Adolescent

KW - Adult

KW - Aged

KW - Cardiovirus Infections

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Infant

KW - Male

KW - Middle Aged

KW - Myocarditis

KW - Pathology, Molecular

KW - Real-Time Polymerase Chain Reaction

KW - Retrospective Studies

KW - Theilovirus

KW - Young Adult

U2 - 10.1016/j.jcv.2015.11.028

DO - 10.1016/j.jcv.2015.11.028

M3 - Letter

C2 - 26687438

VL - 74

SP - 78

EP - 81

JO - Journal of Clinical Virology

JF - Journal of Clinical Virology

SN - 1386-6532

ER -

ID: 172805379

Retsmedicinsk Institut