Serummonitorering af olanzapin under antipsykotisk behandling
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Serummonitorering af olanzapin under antipsykotisk behandling. / Linnet, Kristian; Olesen, Ole Vendelin.
I: Ugeskrift for Laeger, Bind 162, Nr. 36, 04.09.2000, s. 4802-4805.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Serummonitorering af olanzapin under antipsykotisk behandling
AU - Linnet, Kristian
AU - Olesen, Ole Vendelin
PY - 2000/9/4
Y1 - 2000/9/4
N2 - Olanzapine steady-state serum concentrations of 334 patients were measured by high pressure liquid chromatography. The patients were subjected to routine therapeutic drug monitoring of antipsychotic treatment. In cases with more than one serum determination per patient, only the first measurement was included. Eighty-four percent of the patients received daily doses in the recommended range from 5 to 20 mg. The interval 25-140 nmol/1 covered about 80% of the concentrations observed for the daily dose range 5-20 mg. This interval may be used as a reference for therapeutic drug monitoring of olanzapine, indicating whether a patient has a typical or an atypical concentration level at a given dose. Such a judgment may be helpful in situations characterized by side effects, insufficient effect, doubts about compliance or possible pharmacokinetic interactions.
AB - Olanzapine steady-state serum concentrations of 334 patients were measured by high pressure liquid chromatography. The patients were subjected to routine therapeutic drug monitoring of antipsychotic treatment. In cases with more than one serum determination per patient, only the first measurement was included. Eighty-four percent of the patients received daily doses in the recommended range from 5 to 20 mg. The interval 25-140 nmol/1 covered about 80% of the concentrations observed for the daily dose range 5-20 mg. This interval may be used as a reference for therapeutic drug monitoring of olanzapine, indicating whether a patient has a typical or an atypical concentration level at a given dose. Such a judgment may be helpful in situations characterized by side effects, insufficient effect, doubts about compliance or possible pharmacokinetic interactions.
UR - http://www.scopus.com/inward/record.url?scp=0034605092&partnerID=8YFLogxK
M3 - Tidsskriftartikel
C2 - 10994377
AN - SCOPUS:0034605092
VL - 162
SP - 4802
EP - 4805
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 36
ER -
ID: 230032950