Toxicology Screening in Sports-Related Sudden Cardiac Death: A Multinational Observational Study
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Toxicology Screening in Sports-Related Sudden Cardiac Death : A Multinational Observational Study. / Hansen, Carl J; Svane, Jesper; Palsøe, Marie K; Isbister, Julia C; Paratz, Elizabeth; Molina, Pilar; Morentin, Benito; Winkel, Bo G; La Gerche, André; Linnet, Kristian; Banner, Jytte; Lucena, Joaquin; Semsarian, Christopher; Tfelt-Hansen, Jacob.
I: JACC: Clinical Electrophysiology, Bind 10, Nr. 3, 2024, s. 515-523.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Toxicology Screening in Sports-Related Sudden Cardiac Death
T2 - A Multinational Observational Study
AU - Hansen, Carl J
AU - Svane, Jesper
AU - Palsøe, Marie K
AU - Isbister, Julia C
AU - Paratz, Elizabeth
AU - Molina, Pilar
AU - Morentin, Benito
AU - Winkel, Bo G
AU - La Gerche, André
AU - Linnet, Kristian
AU - Banner, Jytte
AU - Lucena, Joaquin
AU - Semsarian, Christopher
AU - Tfelt-Hansen, Jacob
N1 - Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved.
PY - 2024
Y1 - 2024
N2 - BACKGROUND: Knowledge of toxicological findings among sports-related sudden cardiac death (SrSCD) is scarce.OBJECTIVES: This study aimed to describe postmortem toxicology findings in a multinational cohort of young SrSCD.METHODS: Patients with sudden cardiac death (SCD) aged 12 to 49 years with a complete post mortem were included from Denmark, Spain, and Australia. Postmortem findings were compared between SrSCD and non-SrSCD, and toxicology findings in SrSCD were assessed.RESULTS: We included 3,189 SCD, of which 219 (7%) were sports-related. SrSCD patients were younger (36 years vs 41 years; P < 0.001) and of male predominance (96% vs 75%; P < 0.001), and their death was more often caused by structural cardiac disease (68% vs 61%; P = 0.038). Positive toxicology screenings were significantly less likely among SrSCD than non-SrSCD (12% vs 43%; P < 0.001), corresponding to 82% lower odds of a positive toxicology screening in SrSCD. Patient characteristics were similar between SrSCDs with positive and negative toxicology screenings, but deaths were more often unexplained (59% vs 34%). Nonopioid analgesics were the most common finding (3%), and SCD-associated drugs were detected in 6% of SrSCD. SUD was more prevalent among the SrSCD with positive toxicology (59% vs 34%).CONCLUSIONS: Sports-related SCD mainly occurred in younger men with structural heart disease. They had a significantly lower prevalence of a positive toxicology screening compared with non-SrSCD, and detection of SCD-associated drugs was rare.
AB - BACKGROUND: Knowledge of toxicological findings among sports-related sudden cardiac death (SrSCD) is scarce.OBJECTIVES: This study aimed to describe postmortem toxicology findings in a multinational cohort of young SrSCD.METHODS: Patients with sudden cardiac death (SCD) aged 12 to 49 years with a complete post mortem were included from Denmark, Spain, and Australia. Postmortem findings were compared between SrSCD and non-SrSCD, and toxicology findings in SrSCD were assessed.RESULTS: We included 3,189 SCD, of which 219 (7%) were sports-related. SrSCD patients were younger (36 years vs 41 years; P < 0.001) and of male predominance (96% vs 75%; P < 0.001), and their death was more often caused by structural cardiac disease (68% vs 61%; P = 0.038). Positive toxicology screenings were significantly less likely among SrSCD than non-SrSCD (12% vs 43%; P < 0.001), corresponding to 82% lower odds of a positive toxicology screening in SrSCD. Patient characteristics were similar between SrSCDs with positive and negative toxicology screenings, but deaths were more often unexplained (59% vs 34%). Nonopioid analgesics were the most common finding (3%), and SCD-associated drugs were detected in 6% of SrSCD. SUD was more prevalent among the SrSCD with positive toxicology (59% vs 34%).CONCLUSIONS: Sports-related SCD mainly occurred in younger men with structural heart disease. They had a significantly lower prevalence of a positive toxicology screening compared with non-SrSCD, and detection of SCD-associated drugs was rare.
U2 - 10.1016/j.jacep.2023.11.006
DO - 10.1016/j.jacep.2023.11.006
M3 - Journal article
C2 - 38127009
VL - 10
SP - 515
EP - 523
JO - JACC: Clinical Electrophysiology
JF - JACC: Clinical Electrophysiology
SN - 2405-5018
IS - 3
ER -
ID: 378130563