Venovenøs hæmodiafiltrering til baclofenforgiftet patient
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Venovenøs hæmodiafiltrering til baclofenforgiftet patient. / Nielsen, Simon Uhl; Jansen, Tejs; Johansen, Sys Stybe; Linnet, Kristian; Gregersen, Peter; Høgberg, Lotte Christine Groth.
I: Ugeskrift for Laeger, Bind 173, Nr. 22, 2011, s. 1578-9.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Venovenøs hæmodiafiltrering til baclofenforgiftet patient
AU - Nielsen, Simon Uhl
AU - Jansen, Tejs
AU - Johansen, Sys Stybe
AU - Linnet, Kristian
AU - Gregersen, Peter
AU - Høgberg, Lotte Christine Groth
PY - 2011
Y1 - 2011
N2 - Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.
AB - Twice a young man was admitted to hospital upon having taken baclofen overdoses by intention. The ingested dose was 1,850 mg at the first episode and up to 2,500 mg at the second. In both cases the patient had severe overdose symptoms and scored 4-5 on the Glascow Coma Scale and was admitted to intensive care. Continuous venovenous hemodiafiltration (CVVHDF) was initiated. The elimination pharmacokinetics and toxicokinetics for baclofen is not fully known. During the second submission a shorter elimination half-life time was observed and it might be due to either compartmental distribution of baclofen, or more likely caused by an advantageous effect of the CVVHDF.
KW - Baclofen
KW - Drug Overdose
KW - Half-Life
KW - Hemofiltration
KW - Humans
KW - Male
KW - Muscle Relaxants, Central
KW - Suicide, Attempted
KW - Young Adult
M3 - Tidsskriftartikel
C2 - 21627904
VL - 173
SP - 1578
EP - 1579
JO - Ugeskrift for Laeger
JF - Ugeskrift for Laeger
SN - 0041-5782
IS - 22
ER -
ID: 33692377