A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein

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Standard

A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein. / Ejsing, Thomas Broeng; Morling, Niels; Linnet, Kristian.

I: Drug Metabolism and Drug Interactions, Bind 22, Nr. 2-3, 2007, s. 113-29.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Ejsing, TB, Morling, N & Linnet, K 2007, 'A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein', Drug Metabolism and Drug Interactions, bind 22, nr. 2-3, s. 113-29.

APA

Ejsing, T. B., Morling, N., & Linnet, K. (2007). A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein. Drug Metabolism and Drug Interactions, 22(2-3), 113-29.

Vancouver

Ejsing TB, Morling N, Linnet K. A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein. Drug Metabolism and Drug Interactions. 2007;22(2-3):113-29.

Author

Ejsing, Thomas Broeng ; Morling, Niels ; Linnet, Kristian. / A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein. I: Drug Metabolism and Drug Interactions. 2007 ; Bind 22, Nr. 2-3. s. 113-29.

Bibtex

@article{0f23e3508e5811de8bc9000ea68e967b,
title = "A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein",
abstract = "This overview on the brain-serum relationship for drugs illustrates the importance of the drug transporter P-glycoprotein at the blood-brain barrier. Generally, an inverse relationship exists between the magnitude of the brain-serum ratio and the influence of P-glycoprotein. Concerning the pharmacogenomics of P-glycoprotein, no clear effect of single nucleotide polymorphisms (SNPs) has been demonstrated in humans.",
author = "Ejsing, {Thomas Broeng} and Niels Morling and Kristian Linnet",
note = "Keywords: Animals; Blood-Brain Barrier; Brain; Humans; Mice; P-Glycoprotein; Pharmaceutical Preparations; Pharmacokinetics; Rats; Structure-Activity Relationship",
year = "2007",
language = "English",
volume = "22",
pages = "113--29",
journal = "Drug Metabolism and Drug Interactions",
issn = "2363-8907",
publisher = "De Gruyter",
number = "2-3",

}

RIS

TY - JOUR

T1 - A review on the relation between the brain-serum concentration ratio of drugs and the influence of P-glycoprotein

AU - Ejsing, Thomas Broeng

AU - Morling, Niels

AU - Linnet, Kristian

N1 - Keywords: Animals; Blood-Brain Barrier; Brain; Humans; Mice; P-Glycoprotein; Pharmaceutical Preparations; Pharmacokinetics; Rats; Structure-Activity Relationship

PY - 2007

Y1 - 2007

N2 - This overview on the brain-serum relationship for drugs illustrates the importance of the drug transporter P-glycoprotein at the blood-brain barrier. Generally, an inverse relationship exists between the magnitude of the brain-serum ratio and the influence of P-glycoprotein. Concerning the pharmacogenomics of P-glycoprotein, no clear effect of single nucleotide polymorphisms (SNPs) has been demonstrated in humans.

AB - This overview on the brain-serum relationship for drugs illustrates the importance of the drug transporter P-glycoprotein at the blood-brain barrier. Generally, an inverse relationship exists between the magnitude of the brain-serum ratio and the influence of P-glycoprotein. Concerning the pharmacogenomics of P-glycoprotein, no clear effect of single nucleotide polymorphisms (SNPs) has been demonstrated in humans.

M3 - Journal article

C2 - 17708063

VL - 22

SP - 113

EP - 129

JO - Drug Metabolism and Drug Interactions

JF - Drug Metabolism and Drug Interactions

SN - 2363-8907

IS - 2-3

ER -

ID: 13918172